There are 130 million Ethereum addresses and only 4 million addresses interacted with DeFi protocols.

Can this be true? TVL is around 110B all protocols combined, only 4M addresses are responsible for this TVL?

The numbers are backed by Dune analytics https://dune.xyz/rchen8/defi-users-over-time

Metamask got 11M active users what exactly 7M users do (11(metamask users)-4(DeFi users)) ?